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AGE-RAGE系统与糖尿病神经病变 被引量：2

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摘要 糖尿病神经病变的发病机制到目前为止还尚未完全明确,晚期糖基化终产物(AGEs)的过多形成及与其受体(RAGE)的相互作用是其重要机制之一。本文从AGEs在外周神经中的形成特点、RAGE的表达分布和调节、AGEs-RAGE系统在糖尿病神经病变发病中的作用及其可能机制等方面作了综述,并对可通过阻断AGEs-RAGE系统而治疗糖尿病神经病变的药物进展作了概括。
作者 陈笑蟾 沈建国
机构地区 浙江大学医学院附属第一医院内分泌科
出处 《国际神经病学神经外科学杂志》 2007年第3期270-273,共4页 Journal of International Neurology and Neurosurgery
关键词 晚期糖基化终产物 晚期糖基化终产物受体 糖尿病神经病变 AGE-RAGE系统
分类号 R587.2 [医药卫生—内分泌]
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参考文献21

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同被引文献26

  • 1汤正义.糖尿病周围神经病变客观检查方法的应用和研究现状[J].内科理论与实践,2007,2(3):157-159. 被引量：12
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  • 3Natalia VB, Alexander DV. Reprint of The role of cytoskeleton in the regulation of vascular endothelial barrier function. Microvasc Res, 2009, 77 ( 1 ) : 64-69.
  • 4Giaccari A, Sorice G, Muscogiuri G, et al. Glucose toxicity: The leading actor in the pathogenesis and clinical history of type 2 diabetes-mechanisms and potentials for treatment. Nutr Metab Cardiovase Dis, 2009, 19(5) : 365-377.
  • 5Anuran C, John DC. Endothelial nitricoxide (NO) and it spathophy siologic regulation. Vascul Pharmacol, 2008, 49 (4-6):134-140.
  • 6Sunil P, Mahendra K. NO/peroxynitrite dynamics of highglucose-exposed HUVECs: Chemiluminescent measurement computationmodel. Microvasc Res, 2009, 78 ( 2 ) : 191 -198.
  • 7Tetsuya H, Tatsuro I, Husni MC, et al. Endothelial cell-selective adhesion molecule regulates albuminuria indiabetic nephropathy. Microvascu Res, 2009, 77 ( 3 ) : 348-355.
  • 8Daniela M, Karla L, Frank H, et al. Impact of diabetic serum on endothelial cells: An in-vitro-analysis of endothelial dysfunction in diabetes mellitus type 2. Bioehem Biophys Res Commun, 2007, 362(2): 238-244.
  • 9Gabriela O, Jorge P, Glaxo SK, et al. The Pathologic Continuum of Diabetic Vascular Disease. J Am Coll Cardiol, 2009, 2(3) : 35-42.
  • 10Josefa G, Josep MM, Francesc M, et al. Oxidized to non- oxidized lipoprotein ratios are associated with arteriosclerosis and the metabolic syndrome in diabetic patients. Nutr Metabol Cardiovasc Dis, 2008, 18(5) : 380-387.

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国际神经病学神经外科学杂志
2007年 第3期

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