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Notch信号通路与神经系统疾病 被引量：1

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摘要 Notch信号通路存在于多种动物体内,是许多重要细胞信号转导通路的交汇点,在胚胎发育中对细胞的命运决定起关键作用。Notch信号转导紊乱将导致很多神经系统疾病的发生。本文对Notch信号通路组成、功能、与神经系统发育和某些疾病的关系进行综述。
作者 付剑亮 孙晓江
机构地区 上海交通大学附属第六人民医院神经内科
出处 《国际神经病学神经外科学杂志》 2007年第3期293-296,共4页 Journal of International Neurology and Neurosurgery
关键词 NOTCH 信号通路 神经系统疾病
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献14

  • 1易海波,石松生,杨卫忠.Notch信号通路与脑肿瘤[J].国际神经病学神经外科学杂志,2005,32(6):566-569. 被引量：5
  • 2Lasky JL,Hong Wu H.Notch Signaling,Brain Development,and Human Disease.Pediatr Res,2005,57 (5):104-109.
  • 3Wilson A,Radtke F.Notch modulates Multiple functions of Notch signaling in self-renewing organs and cancer.FEBS Lett,2006,580(12):2860-2868.
  • 4Hurlbut GD,Kankel MW,Lake RJ,et al.Crossing paths with Notch in the hyper-network.Curr Opin Cell Biol,2007,19(2):1-10.
  • 5Katsube K,Sakamoto K.Notch in vertebrates-molecular aspects of the signal.Int J Dev Biol,2005,49 (2-3):369 -374.
  • 6De La Coste A,Freitas AA.Notch signaling:Distinct ligands induce specific signals during lymphocyte development and maturation.Immunol Lett,2006,102(1):1-9.
  • 7Suzuki T,Chiba S.Notch signaling in hematopoietic stem cells.Int J Hematol,2005,82(4):285-294.
  • 8Katsube K,Sakamoto K.Notch in vertebrates-molecular aspects of the signal.Int J Dev Biol,2005,49 (2-3):369-374.
  • 9Presente A,Boyles RS,Serway CN,et al.Notch is required for long-term memory in Drosophila.Proc Natl Acad Sci USA,2004(6):1764-1768.
  • 10Uyguner ZO,Siva A,Kayserili H,et al.The R110C mutation in Notch3 causes variable clinical features in two Turkish families with CADASIL syndrome.J Neurol Sci,2006,246(1-2):123-130.

二级参考文献24

  • 1Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate fate control and signal integration in development. Science. 1999,284(5415) :770-776.
  • 2Allman D, Aster JC, Pear WS. Notch signaling in hematopoiesis and early lymphocyte development. Immunol Rev. 2002, 187:75 -86.
  • 3Miele L, Osborne B. Arbiter of differentiation and death: Notch signaling meets apoptosis. J Cell Physiol . 1999,181 (3) :393-409.
  • 4Milner LA, Bigas A. Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation. Blood. 1999,93(8) :2431-2448.
  • 5Lai EC. Notch cleavage: Nicastrin helps Presenilin make the final cut. Curr Biol. 2002,12 ( 6 ) : R200-202.
  • 6Ordentlich P, Lin A, Shen CP, et al. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol. 1998,18(4) :2230-2239.
  • 7Matsuno K, Ito M, Hori K, et al. Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development. 2002,129 ( 4 ) : 1049-1059.
  • 8Ronchini C, Capobianco AJ. Induction of cyclin D 1 transcription and CDK2 activity by Notch ( ic ) : implication for cell cycle disruption in transformation by Notch ( ic ). Mol Cell Biol. 2001 , 21(17) ,5925-5934.
  • 9Hansson EM, Lendahl U, Chapman G. Notch signaling in development and disease. Semin Cancer Biol. 2004 , 14 ( 5 ) : 320-328.
  • 10Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med. 2002,8 ( 9 ) :979-986.

共引文献4

同被引文献15

  • 1杨兆瑞,吴晴,李大卫,陈嘉薇.Notch1和HIF-1α蛋白在胃癌中的表达及临床意义[J].山西医科大学学报,2007,38(6):498-502. 被引量：4
  • 2姜昕,周建华.Notch信号通路及其在肺癌发生中的作用[J].国际病理科学与临床杂志,2007,27(3):231-234. 被引量：11
  • 3Mumm JS,Schroeter EH,Saxena MT,et al.A ligand-inducedextracellular cleavage regulates gamma-secretase-like p roteolyticactivation of Notch1[J].Mol Cell,2000,5 (2):197.
  • 4Schroeder T,Just U.mNotch1 signaling reduces proliferation ofmyeloid progenitor cells by altering cell-cycle kinetics[J].ExpHematol,2000,28 (11):1206.
  • 5Iso T,KedesL,Hamamori Y.HES and HERP families:Multipleeffectors of the Notch signaling pathway[J].J Cell Physiol,2003,194 (3):237-255.
  • 6Logeat F,Bessia C,Brou C,et al.The Notch1 receptor is cleavedconstitutively by a furin-like convertase[J].Proc NatlAcad SciUSA,1998,95 (14):8108.
  • 7Sander GR,Powell BC.Expression of notch receptors and ligandsin the adult gut[J].J Histochem Cytochem,2004,52 (4):509.
  • 8Croquelois A,Blindenbacher A,Terracciano L,et al.Inducibleinactivationof Notch1 causes nodular regenerative hyperplasia[J].Hepatology,2005,41(3):487-496.
  • 9Huang J,Zhang X,Zhu J D,et al.Up-regulation of DL K1 as animprinted gene could cont ribute to human hepatocellularcarcinoma[J].Carcinogenesis,2007,28(5):1094 -1103.
  • 10吕伟,陈凛,孙锁柱.应用组织芯片技术研究Della-like 4在胃癌组织中的表达及意义[J].世界华人消化杂志,2008,16(9):956-961. 被引量：7

引证文献1

国际神经病学神经外科学杂志
2007年 第3期

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