期刊文献+

帮助科学家检测组织样品中药物的系统

A System That Helps Scientists See Drugs in Tissue Samples
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摘要 观察候选药物在目标组织中的分布能够帮助科学家更好地评估该化合物作为药品的可能性。质谱组织成像技术能够提供这方面的信息。本文介绍了如何利用该技术研究候选药物在大鼠和小鼠组织中的图像定位。 Being able to observe the distribution of a drug candidate in a targeted tissue sample helps scientists to better assess the potential value of the compound as a pharmaceutical entity. A novel technique called mass spectrometry tissue imaging provides this information, and an account is provided of the visualization of difference regions within rat and mouse tissues in which candidate drug compounds were located.
作者 Mark Springer
机构地区 Applied Biosystems
出处 《生命科学仪器》 2007年第6期40-42,共3页 Life Science Instruments
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参考文献3

  • 1[1]Korfmacher WA.Bioanalytical assays in a drug discovery environment.In:Korfmacher W,ed.Using mass spectrometry for drug metabolism studies.Boca Raton,FL:CRC Press,2002:305-28.
  • 2[2]Reyzer ML,Hsieh Y,Ng K,Korfmacher WA,Caprioli RM.Direct analysis of candidate drags in tissue by matrix-assisted laser desorption/ionization mass spectrometry.J Mass Spec,2003,38:1081-92.
  • 3[3]Reyzer ML,Caprioli RM.MS imaging:new technology provides new opportunities.In:Korfmacher W,ed.Using mass spectrometry for drug metabolism studies.Boca Raton,FL:CRC Press,2004:305-28.

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