120例大肠癌临床病理因素与预后关系探讨

THE STUDY OF CLINICOPATHOLOGIC FEATURES IN RELATION WITH PROGNOSIS OF COLORECTSL CARCINOMA: A REPORT OF 120 CASES

对120例大肠癌病例进行分子生物学研究。运用免疫组化方法检测其P53蛋白表达频率及多个临床病理学指标与预后之间关系。结果发现P53蛋白在大肠癌中的表达为66．7％，运用COX模型对P53蛋白、发病年龄、性别、病程、肿瘤大小、原发部位、浸润程度、病理类型、淋巴结转移以及Dukes分期等进行分析。结果显示：大肠癌P53蛋白表达与肿瘤发病年龄、原发部位，大体分型明显相关。其预后分析中发现：P53蛋白阳性组复发率及死亡率均高于阴性组，提示P53蛋白可以作为一个预后的生物学指标。

The expressive frequency of the P53 gene in the resectedtumor was studied in 120 patients with colorectal cancer byimmunohistochemistry (60 cases in the prospective & 60 cases in the retrospective group) the correlation with other clinicopathological factors and the prognosis of the disease was explored. The result showed that the frequency of the P53 expression in colorectal cancer reached 66. 7 %. The correlationof the gene and age, sex, duration of symptoms. size & siteof tumor. depth of invasion, pathological types, lymphnodemetastasis and Dukes staging was analyzed by Cox model. Expression of the P53 protein was significantly correlatedwith age, size of tumor and gross pathological types. Theanalysis of the prognostic role showed that the recurrence andmortality rates of the P53 protein - negative group were significantly higher than those of the P53 protein -negativegroup, which suggested that the P53 protein might be a biological Prognostic marker.