异丙酚临床药物动力学研究

Study on Pharmacokinetics of propofol

本文采用高效液相色谱法测定血浆中异丙酚浓度，研究８例异丙酚诱导静脉麻醉手术患者的药物动力学特征。结果表明：异丙酚诱导静脉麻醉符合开放性三室模型特征，具有分布快，分布广，清除率高等特性。其药物动力学参数分别为：Ｔ１／２α＝０．０１１±０．００２ｈ，Ｔ１／２β＝０．１９±０．１１ｈ，Ｔ１／２γ＝２．６±１．０ｈ，Ｖ＝５．０±２．５Ｌ／ｋｇ，Ｃｌ＝１．５７±０．２４Ｌ／（ｋｇ·ｈ）

This paper studied on the pharmacokinetics of propofol(2,6 diisopropylphenol)as iv induction anesthetic and propofol in vivo was assayed with RP HPLC method.The result showed the pharmacokinetics of propofol fitted in with a three compartment open model( n =8).The main parameters( T 1/2α ,T 1/2β ,T 1/2γ ,Vd,Cl )were 0.011 h, 0.19h , 2.6 h, 5.0 L/kg, 1.57 L/(kg·h)respectively.