摘要
本文介绍了贝叶斯法的基本原理及有关公式。以双氯芬酸钠普通注射剂和冻干注射剂为实验药物,给予12名健康受试者分别肌内注射两制剂一次剂量(75mg)后,于高效液相色谱中测定血浆药物浓度,计算药物动力学参数AUC、Cmax和Tmax值。以这3个动力学参数为基本数据。
In this paper the primary theory and formularies of Bayesian method were introduced.After intramuscular injection of two formulations of diclofenac sodium (solution 75mg/3ml and lyophilized 75mg/+1ml) in twelve healthy volunteers,the plasma concentration was determined by HPLC.The pharmacokinetic parameters AUC、T max and C max were calculted.The experimental procedure and bioequivalence assessment were described with Bayesian method.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1997年第2期53-55,共3页
Chinese Journal of Hospital Pharmacy