罗红霉素灌胃后胆汁、血中药物动力学的动物实验研究

Pharmacokinetic study of roxithromycin in the bile and the blood of dogs

为了给胆道感染的病人提供合理的口服抗生素的依据，我们用狗胆道造瘘的方法，观察了经口给予罗红霉素后，该药在胆汁、血中的药物动力学变化规律。结果表明狗口服罗红霉素０．１５ｇ／条，０．５ｈ后，胆汁浓度迅速上升，１ｈ左右达峰值，Ｃｍａｘ为２１．５３μｇ／ｍｌ，Ｔ１／２β为２．６６ｈ，Ｃｌ为４０ｍｌ／ｍｉｎ，Ｖｄ为８．４６Ｌ。由于口服罗红霉素后，胆汁中浓度迅速上升。

The pharmacokinetic study of roxithromycin in dog′s blood and bile was performed and compared with the blood and bile.After 0.15/dog roxithromycin by po,maxinum concentration ( C max ) in the bile was 21.53μg/ml.The biriary elimination half time ( T 1/2β )was 2.66 hours.The apparent volume of distribution ( Vd ) in the bile was 8.45 L.40ml/min.As maintain the higher concentration level for long time in the bile,roxithromycin were recommened useing in patients of a infections int the biriary truct.