期刊文献+

两种微囊化β-胡萝卜素干粉在水中的溶解性能

Dissolution characteristics of two kinds of microencapsulated β-carotene powder in water
下载PDF
导出
摘要 溶解性能是粉粒状物质的一个重要理化指标,但在测量过程中由于细小微粉易结“团块”并黏附在器壁或搅拌桨上,会影响测量结果。本研究自行设计了一个新的实验装置,以水分散液色度作为监控指标,可以准确地测定微囊化β-胡萝卜素干粉在水中的溶解性能。通过分析其溶解动力学和溶解活化能,找出了其溶解行为的限速因子,并提出了改善其溶解性能的对策,对优化微囊化β-胡萝卜素干粉的配方具有很好的指导意义。 Dissolution characteristics is an important index for soluble powder, however, the experimental results are always irreproducible because of the fine powder's lump-formation or conglutination tendency. In this work, a simple apparatus for determining the dissolution properties of soluble β-carotene powder was designed and set up to resolve these problems. Through monitoring the increase in solution chroma, the dissolution characteristics of two kinds of microencapsulated β-carotene powder in water were investigated, and a parameter for the deliquescent portion was determined as a function of time. Relative dissolution curves were plotted and dissolution kinetics as well as dissolution activation energy were analyzed. Based on the key factors for powder dispersion or dissolution obtained, this method can be used to improve the dissolution abilities.
出处 《化工学报》 EI CAS CSCD 北大核心 2007年第7期1792-1797,共6页 CIESC Journal
基金 国家自然科学基金项目(20576118)~~
关键词 Β-胡萝卜素 微囊化干粉 溶解性能 水分散液色度 溶解动力学 溶解活化能 β-carotene microencapsulated powder dissolution characteristics solution chroma dissolution kinetics dissolution activation energy
  • 相关文献

参考文献14

  • 1Devotta I,Ambeskar V D,Mandhare A B.The life time of a dissolving polymeric particle.Chemical Engineering Science,1994,49:645-654.
  • 2Brittain H G.Physical Characterization of Pharmaceutical Solids.New York:Marcel Dekker,1995:25.
  • 3To K M,Mithchell J R,Hill S E,Matthews P.Measurements of hydration of polysaccharides.Food Hydrocolloids,2004,8:243-249.
  • 4Schubert H.Principles of agglomeration.Int.Chem.Eng.,1981,21(3):363-377.
  • 5Smidsrod O,Haug A.The effect of divalent metals on the properties of alginate solutions(Ⅰ):Calcium ions.Acta Chemica Scandinavica,1995,19:329-340.
  • 6Christian K L,Olav G,Olav S.A novel method for measuring hydration and dissolution kinetics of alginate powders.Carbohydrate Polymers,2003,51:125-134.
  • 7Barbara F,Stefan H,Helmar S.Dispersion of powders in liquids in a stirred vessel.Chemical Engineering and Processing,1999,38:525-532.
  • 8Treml H,Kohler H H.Coupling of diffusion and reaction in the process of capillary formation in alginate gel.Chemical Physics,2000,252:199-208.
  • 9Ranade V V,Mashelkar R A.Convective diffusion from a dissolving polymeric particle.American Institute of Chemical Engineering J.,2005,41:666-676.
  • 10Ciofalo M,Brucato A,Grisafi N.Turbulent flow in closed and free-surface unbaffled tanks stirred by radial impellers.Chem.Eng.Sci.,1996,51(14):3557-3573.

二级参考文献18

  • 1Base A,van den Berg H,van den Plas R M.β-Carotene as antioxidant.Eur.J.Clin.Nutrition,1996,50:554-556
  • 2Blumberg J,Block G.The β-tocopherol,β-carotene cancer prevention study in Finland.Nutritin Review,1994,52:242-245
  • 3Adolfsson A,Nystrom C.Tablet strength,porosity,elasticity and solid state structure of tablets compressed at high loads.Int.J.Pharma.,1996,132:95-106
  • 4Fernandez-Herras M J,Vela M T.Using the percolation theory to explain the release behavior from inert matrix system.Drug Dev.Ind.Pharm.,1996,22:201
  • 5Itzell J R,Rhodes C T.Instrumented tablet press studies on the effect of some formation and process variables.Drug Dev.Ind.Pharm.,1990,16:469
  • 6Hausner H.Friction conditions in a mass of metal powder.Int.J.Powder Metal,1967,3(4):7-13
  • 7Hickey A J,Comcessio N M.Descriptors of irregular particle morphology of powder properties.Advanced Drug Delivery Reviews,1997,26:29-40
  • 8Guerin E,Tchoreloff P,Leclerc B.Rheological characterization of pharmaceutical powders using tap testing,shear cell and mercury porosimeter.Int.J.Pharm.,1999,189:91-103
  • 9Fitzpatrick J J,Barringer S A,Iqbal T.Flow property measurement of food powders and sensitivity of Jenike's hopper design methodology to the measured values.J.Food Engineering,2004,61:399-405
  • 10Wikberg M,Alderborn G.Compression characteristics of granulated materials(Ⅱ):Evaluation of granular fragmentation during compression by tablet permeability and porosity measurements.Int.J.Pharm.,1990,62:229-241

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部