摘要
以2-甲基-6-乙基苯胺(甲乙苯胺)和氯乙酰氯为主要原料,通过正交设计和极差分析讨论了采用间歇法合成乙草胺过程中酰化反应中间体2’-甲基-6’-乙基-2-氯乙酰苯胺(伯酰胺)的产率影响因素。通过极差分析确定,反应时间是影响伯酰胺产率的主要因素。产率较高的反应条件是甲乙苯胺∶氯乙酰氯∶二甲苯=1.0∶0.9∶3.5,时间为85 min;产率为91%。
The yield of acylation, the intermediate of sythesizing acetochlor from the 2 - methyl - 6 - ethylaniline(MEA) and chloracetyl chlorine, was studied through orthogonal test. The influence factors were analysed and results showed that reaction time is the most important factor to the yield ratio. The better yield is 91% under the condition of MEA: chloracetyl chlorine: dimethyl benzene = 1.0:0. 9:3.5.
出处
《辽宁化工》
CAS
2007年第3期155-156,共2页
Liaoning Chemical Industry
关键词
伯酰胺
酰化反应
乙草胺
间歇法
Aeetochlor synthesis
Aeylation
Orthogonal test