摘要
目的:为完善改变剂型的制剂复方杏香兔耳风胶囊的质量控制方法。方法:采用薄层鉴别和高效液相色谱法,以绿原酸为对照品,检测波长为327nm,甲醇-2%冰醋酸溶液(10∶90)为流动相。结果:通过方法学考察,绿原酸进样量在0.0594～0.5348μg范围内,呈良好的线性关系,平均回收率为98.9%,RSD为0.9%。结论:薄层鉴别,方法专属,斑点清晰;含测方法简便,精密度及重复性均好。可有效控制复方杏香兔耳风胶囊的质量。
Objective：In this article,to study quality standard,and edit thin-layer identification and determination method for changing preparation of Fufang Xingxiang Tu＇erfeng Capsule, Methods：Comparison to Chlorogenic Acid standard substance, the Chlorogenic Acid content in capsule was determined by HPLC method, with 327nm as the detection wavelength and methanol-2% glacial acetic acid solution （10 ： 90）as the mobile phase. Results：It was demonstrated,when injected volume of chlorogenic acid ranges from 0. 0594μg to 0. 5348μg,the result has a good linear regression,the average recovery was 98.9%, and RSD was 0.9 %. Conclusion ：This method is accurate and reliable and can be used for differentiating,and determination of chlorogenic acid content.
出处
《中国药品标准》
CAS
2007年第3期58-60,共3页
Drug Standards of China
