乳腺浸润性导管癌间质细胞的组织蛋白酶D表达的预后意义

Prognostic significance of cathepsin D expression by stromal cells of invasive ductal carcinoma of breast

用免疫组化 LSAB 法检测组织蛋白酶 D(CD)在86例乳腺浸润性导管癌的间质细胞和癌细胞中的表达情况。结果:间质细胞和癌细胞的阳性率分别为66.2%(57/86)和54.6%(47/86)。CD 在间质细胞中的表达强度高于癌细胞,差别有显著性意义。统计学分析表明,间质细胞的 CD 高表达与乳癌的区域淋巴结转移、远处转移和小于5年生存期呈正相关,而癌细胞的 CD 表达与上述预后指标无关。说明间质细胞的 CD 表达可作乳癌预后的一种指标。本文还就 CD 在间质细胞的阳性率和表达强度高于癌细胞的意义作了讨论。本研究提示,间质细胞可能在乳癌的局部浸润和转移中起重要作用。

Using LSAB immunohistochemical method,cathepsin D (CD) expression by stromal cells and cancer cells of invasive carcinoma of breast was detected.Results showed that positive rates of CD in stromal and cancer cells were 66.2% (57/86) and 54.6% (47/86),respectively.The staining in- tensity of CD in stromal cells was higher than that in cancer cells,the difference was statistically signif- icant.Statisical analysis showed that high expression of CD by stromal cells (but not by cancer cells) was positively correlated with regional lymph-node and distant metastases and less-5-year survival,and that CD expression by stromal cells may be an indicator of prognosis of breast cancer.The significance of different expressions of CD by stromal and cancer cells was discussed.Our study suggests that stro- mal cellsprobably play an important role in local invasion and metastasis of the tumor.