柳氮磺胺吡啶致急性胰腺炎

Acute pancreatitis caused by sulfasalazine

28岁男性患者,因再发溃疡性结肠炎,口服柳氮磺胺吡啶1g,4次/d,1周后出现上腹部持续性绞痛,恶心、呕吐,血清淀粉酶601U/L,尿淀粉酶1703U/L,诊断为急性胰腺炎入院。立即停用柳氮磺胺吡啶,经对症保守治疗后痊愈出院。随访2年7个月未再复发。

A 28-year-old man with recurrent ulcerative colitis received sulfasalazine lg four times daily. One week later, he developed continual epigastric tormina with nausea and vomiting. His serum amylase level was 601 U/L, and urinary amylase level was 1703 U/L. He was hospitalized with acute pancreatitis. After the discontinuation of sulfasalazine and receiving symptomatic therapy, the patient recovered and was eventually discharged. At follow-up, 2 years and 7 months later, there was no recurrence of the acute pancreatitis.