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Notch信号通路与神经系统肿瘤 被引量：5

Notch signaling in the neural tumorigenesis
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摘要 Notch信号在神经系统的发育过程中对细胞增殖和分化的调控起关键性的作用。Notch信号通路的失调与神经系统肿瘤关系密切,在神经母细胞瘤,胶质瘤,髓母细胞瘤等神经系统来源的肿瘤中均发现Notch信号通路受体、配体及其下游成分的失调。通过对Notch信号通路的调控可以诱导肿瘤细胞的分化及促进死亡,Notch信号分子可作为神经系统肿瘤基因治疗及新药开发的靶点。 Notch signaling plays crucial roles in regulating cell proliferation and differentiation during neurogenesis. Studies on neuroblastoma, glioma and medulloblastoma revealed that neural-derived tumors are associated with dysfunction of Notch receptors, ligands and its downstream components. Notch signal pathway can be a novel target for therapeutic intervention in neural cancers.
作者 郑莺凤 郑志竑
机构地区 福建医科大学分子医学研究中心
出处 《中华肿瘤防治杂志》 CAS 2007年第13期1029-1032,共4页 Chinese Journal of Cancer Prevention and Treatment
关键词 神经系统肿瘤 信号传导 综述文献 nervous system neoplasms signal transduction review literature
分类号 R739.4 [医药卫生—肿瘤]
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参考文献21

  • 1Purow B W,Haque R M,Noel M W,et al.Expression of Notch-1 and its ligands,Delta-Like-1 and Jagged-1,is critical for glioma cell survival and proliferation[J].Cancer Res,2005,65(6):2353-2363.
  • 2Stockhausen M T,Sjound J,Manetopoulos C,et al.Effects of the histone deacetylase inhibitor valproic acid on Notch signaling in human neuroblastoma cells[J].Br J Cancer,2005,92(4):751-759.
  • 3Iso T,Kedes L,Hamamori Y.HES and HERP Families:multiple effectors of the Notch signaling pathway[J].J Cel Physiol,2003,194(3):237-255.
  • 4Grynfeld A,Pahlman S,Axelson H.Induced neuroblastoma cell differentiation,associated with transient Hes-1 activity and reduced Hash-1 expression,is inhibited by Notch-1[J].Int J Cancer,2000,88(3):401-410.
  • 5Park H C,Appel B.Delta-Notch signaling regulates oligodendrocyte specification[J].Development,2003,130(16):3747-3755.
  • 6Yang X,Klein R,Tian X,et al.Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway[J].Dev Biol,2004,269(1):81-94.
  • 7Oishia K,Kamakura S,Isazawa Y,et al.Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis[J].Dev Biol,2004,276(1):172-184.
  • 8Fan X,Mikolaenko I,Elhassan I,et al.Notch1 and Notch2 have opposite effects on embryonal brain tumor growth[J].Cancer Res,2004,64(21):7787-7793.
  • 9Franklin J L,Berechid B E,Cutting F B,et al.Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Deltal[J].Curr Biol,1999,9(24):1448-1457.
  • 10Stockhausen M T,Sjolund J,Axelson H.Regulation of the Notch target gene Hes-1 by TGFa induced Ras/MAPK signaling in human neuroblastoma cells[J].Exp Cell Res,2005,310(1):218-228.

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中华肿瘤防治杂志
2007年 第13期

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