2型糖尿病患者皮肤微血流改变与病程的关系

Relationship Between Cutaneous Microflow's Change and the Duration in Type 2 Diabetes

目的:探讨2型糖尿病患者皮肤微血流改变与其病程的关系。方法:选择2型糖尿病患者中病程≤5年和≥15年者各17例。用皮肤血流阻断后反应性充血(PORH)的方法,以左前臂皮肤为测定点,应用激光多普勒血流仪(LDF)记录阻断前、中、后的皮肤微血流值。结果:短病程组的皮肤微血流最大值明显高于长病程组(27.83±8.83比18.07±6.91,P<0.01);短病程组的皮肤微血管反应性充血速率明显大于长病程组(2.62±1.50比1.57±0.96,P<0.05)。结论:2型糖尿病患者前臂皮肤微血管病变随糖尿病病程延长而加重。

Objective: To study the relationship between the change of cutaneous microflow and the duration of type 2 diabetes.Method: Post-Occlusion Reactive Hyperaemia(PORH)was applied to obstruct the left forearm blood flow. Cutaneous microflow of type 2 diabetic patients whose duration was less than 5 years (n=17) and more than 15 years (n=17) were measured by Laser Doppler Flowmetry (LDF). Results: The maximum cutaneous microflow of left forearm decreased markedly with the duration of type 2 diabetes( P<0.01);The reactive hyperaemia was more rapid in patients with shorter duration (P<0.05).Conclusion: Cutaneous microangiopathy gets worse with the increasing duration in type 2 diabetes.