糖尿病合并动脉粥样硬化患者糖化血红蛋白及血糖、血脂水平分析

Analysis of Glycosylated Hemoglobin,Blood Glucose and Lipids Levels in Diabetes Mellitus Combined with Atherosclerosis Patients

目的:观察糖尿病合并动脉粥样硬化(DM+AS)患者糖化血红蛋白(HbAlc)及血糖、血脂水平的变化。方法:测定32例DM+AS患者、36例单纯糖尿病(DM)患者和55例健康对照者HbAlc、空腹血糖(FBG)和血脂指标,并进行对比分析。结果:DM+AS组与单纯DM组之间FBG水平无显著性差异,HbAlc水平有显著性差异(P<0.05),且两组两指标均较正常对照组显著增高(P<0.01);总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)和脂蛋白(a)[Lp(a)]水平DM+AS组比正常对照组显著增高(P<0.01)。结论:DM+AS患者血脂水平明显升高;HbAlc作为反映血糖控制好坏的有效指标,对DM合并AS及血管病变的监测有重要作用。

Objective: To investigate the relation and change of glycosylated hemoglobin(HbAlc),blood glucose and lipids levels in the course of diabetes combined with atherosclerosis (DM+AS). Method: Glycosylated hemoglobin , fasting blood glucose ,lipids levels were determined in 36 patients with purely diabetes mellitus(DM) and 32 patients with DM+AS ,and 55 healthy controls,then all of the results were statistically analyzed.Results: The level of blood glucose had no significant difference between DM group and DM+AS group, but the level of HbAlc was significantly different in two groups .Blood glucose had a positive correlation with HbAlc. Lipids levels in the patients with DM+AS had obvious significance compared with purely DM and healthy controls.Conclusion: The research indicated that the level of Lipids of patients with DM+AS was significantly higher than that of healthy controls, HbAlc could be regarded as the criterion which represents the control degree of blood glucose, and it is very important to detect HbAlc and prerent the development of vascular pathological changes in the patients with diabetes combined with atherosclerosis.