S100A9在宫颈鳞状细胞癌中的表达

Expression of S100A9 in Cervical Squamous Cell Carcinoma

目的:探讨S100A9在宫颈鳞状细胞癌组织中的表达。方法:采用实时定量RT-PCR的方法检测12例宫颈鳞状细胞癌组织及10例正常宫颈组织中S100A9 mRNA的表达水平。结果:S100A9 mRNA在宫颈鳞状细胞癌组织中的相对表达量为2.72±2.50,在正常宫颈组织中的相对表达量为8.34±2.94,差异具有统计学意义(P<0.01)。结论:S100A9在宫颈鳞状细胞癌组织中表达下调,可能是宫颈鳞状细胞癌变过程中具有抑癌作用的基因。

Objective： To investigate the mRNA expression of S100A9 in cervical squamous cell cancer. Methods： Quantitative real time RT-PCR was used to detect mRNA expression of S100A9 in 12 cervical cancer samples and 9 controls. Results： The relative expression of S100A9 was 2.72±2.50 in the cervical cancer samples and 8.34±2.94 in the controls, and there was a significant difference between the two. Conclusion： The relative expression of S100A9 is lower in cervical cancer patients than in the controls, and this gene may be involved in the pathogenesis of cervical cancer.