颈动脉硬化与血脂、载脂蛋白关系探讨

The Relationship Among Blood Lipids, apolipoprotein amd Carotid Atherosclerosis

目的探讨颈动脉硬化与血液中脂类成分的关系。方法用高频超声观察颈动脉系统斑块的形成及测量颈总动脉内膜一中层厚度（IMT），同时抽血检查血脂及载脂蛋白。结果颈动脉斑块及IMT增厚随年龄增加而明显增多；载脂蛋白apoAI与颈动脉斑块及IMT增厚有明显的负相关，apoAI及apo（AI／B）比值的降低在颈动脉硬化的二组与正常组比较有显著性差异（P〈0.01）；血脂及其他载脂蛋白与颈动脉硬化无明显相关性。结论颈动脉硬化与年龄呈正相关，与载脂蛋白apoAI呈负相关。

Objective Carotid atherosclerosis is common in patients. In this study, we aimed to investigate the relationship between bloodolipids, apoprotein and carotid atherosclerosis. Methods To observe the arteria carotis and it＇s intimal-medial thickness （IMT）by using high-frequency ultrasound, and analyze the blood lipids and apolipoprotein of examination people. Results The carotid atherosclerosis plaque and IMT increased with the age; The relative analysis showed that apoAI was negatively correlated with the carotid atherosclerosis plaque and IMT; The apo（AI/B） decreased in the group of healthy people than the people with carotid atherosclerosis （P〈0.01）, no associativity between blood-lipids, other apoproteins and carotid atherosclerosis. Conclusion There was a positive correlation between carotid atherosclerosis and age, a negatively correlation between carotid atherosclerosis and apoAI.