突发性耳聋患者的血流变学改变

Hemorheological Disorders in Patients with Sudden Deafness

本文观察了59例突聋患者的14项血液流变学及相关指标，并与同期检测的512例健康成人的相关指标进行了对比分析．结果发现，男性患者的全血比粘度、全血还原比粘度和血浆粘度显著高于健康人群。女性患者全血还原比粘度和血浆粘度显著高于健康人群。提示血液流变学改变导致的循环障碍与突聋发病有密切关系．影响血浆粘度的因素观察，发现男性患者血浆纤维蛋白原和甘油三酯显著高于对照健康人群，而女性患者则表现胆固醇和甘油三酯显著高于对照组。说明男女患者导致血浆粘度改变的因素不完全相同。提示在突聋的治疗上，应采取降低血液粘度，改善微循环等共同措施外，也应根据不同性别或个体的检测结果，采用适应个体情况的特殊性治疗方案．

Fourteen hemorheological and related parameters of blood samples derived from 59 patients withsudden deafness were observed and were compared with those of blood samples got from 512 healthy persons. Theratio viscosity of whole blood (6. 50±1. 07), reduced viscosity of whole blood (12. 37±1. 80), and plasma viscosi-ty (1. 84±0. 14) in male patients were significantly higher than those (6. 05±0. 63，11. 06 ±1. 04, and 1. 70±0. 07, respectively) in male controls. The reduced viscosity of whole blood (16. 62±3. 87) and plasma viscosity(1. 92±0. 13) in female patients were also significantly higher than those (14. 40±2. 27 and 1. 72±0. 06, respec-tively) in female controls. The findings above suggest that there is an intimate relationship between the microcircu-lationary disorder resulting from hemorheological changes and the onset of sudden deafness. The parameters relat-ed to plasma viscosity revealed that there were higher concentrations of plasma fibrinogen and triglyceride in malepatients than those in male controls, while the concentrations of plasma cholesterol and triglyceride were higher infemale patients than in female controls. These results indicate that the factors which induce the change of plasmaviscosity in male patients could not be the same as those in female patients. Thus, in the process of treating suddendeafness, besides the use of common devices such as reducing blood viscosity and improving microcirculation, someother special steps based on the hemorheological parameters derived from different sexes or individuals, should alsobe considered.