同位素清除法研究不充分减压时小型猪股骨血流量的变化

Ateration in Regional Blood Flow in Minipigs' Femur under Inadequate Decompression Studied by Isotopes Washout Method

本文研究了小型猪在高气压暴露不充分减压后股骨局部血流量的变化．动物在0．5MPa高厌空气舱内暴露1．5h，以0．03～004MPa／min匀速减压．骨血流量用吸入133Xe同位素清除法测定。结果为：暴露前平均骨血流量（F），左右侧分别为15.4±1．8和16．9±2．0ml／100g．min，造血骨髓组织血流量（f1）是19．1±2．0和21．3±2．1ml／100g·min（n=7）．不充分减压后，F值降至10．3±1．8和11．1±1．6ml／100g·min，f1值降至13．9±1．4和13．8±1．0ml／100g·min，明显低于暴露前值（P＜0.05）．本研究表明：高气压暴露不充分减压可引起小型猪骨血流量降低．提示，骨供血不足是诱发减压性骨坏死的病因之一．

We studied the alteration in regional blood now in minipigs' femur under inadequate decompressionafter hyperbaric air exposure. The animals were placed in the hyperbaric chamber and exp0sed to the pressure of0. 5 MPa for 1. 5 h, which was reduced to atmosphere at an ascent rate of 0. 03-0. 04 MPa/min. Regional bloodflow in the femur was measured by the isotopes washout method of inhaling 133Xe. The radioactivity was moni-tored by a multifunctional blood flowmeter interfaced to a minicomputer. Before exposure, the values of averageblood flow (F) of femur on the left and right were 15. 4±1. 8 and 16. 9±2. 0 ml/100g· min respectively. The val-ues of blood now (f1) of hematopoietic marrow were 19. 1±2. 0 and 21. 31±2. 0 ml/100g·min(n=7). After inade-quate decompression, F values were reduced to 10. 3±1. 8 and 11. 1±1. 6 ml/100g· min and f1 values reduced to13. 9±1. 4 and 13. 8±1. 0ml/100g· min (n=7), which were obviously lower than those before exposure (P<0. 05). This experiment showed that significant reduction in blood flow in the femur region occurred under inade-quate decompression after the exposure of minipigs hyperbaric environment, suggesting that ischemia is a causativefactor of osteonecrosis-