胰舒血管素、糜蛋白酶、磷脂酶A_2、胶原酶、促胰酶素及脂肪酶对红细胞悬浮液粘弹特性的影响

Effects of Vasoactive Intestinal peptide,α-Chymotrypsin,Pancreozymin,Lipase, Phospholipase A_2 and Collagenase on the Viscoelasticity Properties of Red Blood Cell Suspension

急性坏死性胰腺炎存在着血液流变学指标增高的现象，为了探讨其血液流变学指标增高的原因，本文采用LowShear－30流变测定仪在体外测定了不同浓度的胰舒血管素、糜蛋白酶、磷脂酶A2、胶原酶、促胰酶素和脂肪酶等六种物质对红细胞悬浮液粘弹特性的影响，并与对照组相比较．结果显示这六种物质均能使红细胞悬浮液在低切变串下表现粘度（η0.512）及红细胞聚集指数（A．I．）增高（P＜0．005）．表明这六种物质均能使红细胞聚集增加．而各种药物间及各浓度组间无显著性差异（P＞0.05）。

Using Low Shear-3O Rheometer, we studied the effects of vasoactive intestinal peptide, α-chy-motrypsin, pancreozymin, lipase,phospholipase A2 and collagenase on the viscoelasticity properties of RBC suspen-sion. The result showed that these drugs could increase the values of η0.512 and A. I. It suggests that these drugscould increase the degree of RBC aggregation. Among the drugs and concentrations, there is no significant differ-ence.