宿主细胞泛素系统与病毒相互作用的研究

Research progress of interaction betwwen host UPP and virion

真核细胞中,泛素系统执行对大多数短周期寿命蛋白的选择性降解,且已发现由泛素介导的对蛋白的降解调控在细胞的多种生命过程中起重要作用。病毒侵染宿主细胞后,细胞的泛素系统与一些重要的病毒蛋白相互作用,参与调节病毒的生活周期,如病毒迁移,核酸复制,免疫逃避,出芽等过程。

Ubiquitin proteasome pathway is responsible for the degradation of Short life protein in the eukaryote, UPP is high selective and very important in regulating various cellular processes. UPP of host cell is involved in the assembly or budding of virions from host cells ,virion DNA replication and help Virion escape from the monitor of host immune system by regulating the degradation of specific host or viral proteins.