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HLAⅠ类分子作为细菌受体的可能性观察 被引量:1

An Observation on the Possibility of HLA Class Ⅰ Molecules as Bacterial Receptor
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摘要 为探讨细胞表面HLAⅠ类抗原分子作为细菌受体的可能性,用10属16种21株细菌,8份7个特异性的抗血清,对108份健康志愿者外周血淋巴细胞进行了细胞毒抑制试验。结果表明,10属中有8属细菌在处理淋巴细胞后,能封闭淋巴细胞抑制其相应抗体的细胞毒作用。这种抑制能力有限,且缺乏严格的菌株、抗体或淋巴细胞特异性。本研究提示,有些细胞表面的HLAⅠ类分子能够和细菌结合,但其在传染发生上的意义。 In order to determine the possibility of HLA class I antigen molecules as bacterial receptor,cytotoxicity inhibition test was carried out with 21 strains of bacteria,belong to 16 species of 10 genera of bacteria,8 antisera of 7 specificity and 108 healthy volunteer lymphocytes.The results showed: after treating lymphocytes,8 out of 10 genera bacteria were able to inhibite the cytotoxicity effect of different antiserum.However,there was no strict specificity in bacterial strain,antiserum or lymphocyte.Although some HLA class I molecules on cell surface are able to combine bacteria,their role in infection still need to be studied.
作者 刘若英
出处 《贵阳医学院学报》 CAS 1997年第1期1-4,共4页 Journal of Guiyang Medical College
基金 卫生部资助课题
关键词 人类白细胞抗原 细菌 细胞毒抑制试验 淋巴细胞 HLA bacterium lymphocyte cytotoxicity inhibition test
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