AgNOR在肾盂癌中的表达及临床意义

Expression of AgNOR in renal pelvis cancar and its clinical significance

为探讨细胞核仁组成区相关嗜银蛋白（AgNOR）在肾盂癌中的表达，对29例肾盂癌和10例正常肾盂组织标本进行了银染色。结果表明，肾盂癌AgNOR计数明显高于正常肾盂组织（P＜0．01）；AgNOR计数随肿瘤病理分级和分期的上升而增加。还发现肾盂癌AgNOR计数＞6时，75％的患者术后可再发膀胱肿瘤。认为AgNOR颗粒数可作为鉴别良、恶性肾盂病变和评估肾盂癌生物学行为的指标之一。对肾盂癌AgNOR计数＞6者，应按膀胱肿瘤对待。

In order to investigate the expression of AgNOR in renal pelvis cancer,29 cases of renal pelvis cancer and 10 cases of normal renal pelvis tissue were examined using silver-staining.The result showed that there was a significant difference of the mean AgNOR numbers between tumor and normal tissue (P<0. 01 ). The mean AgNOR numbers were increased with tumor grade and stage. Tumor with the AgNOR numbers more than 6 were predisposed to the occurrence of bladder tumor after operation for renal pelvis cancer. These patients should be treated as bladder tumor. The result suggested that AgNOR staining might serve as a useful marker for the differentiation of benign and malignanst renal pelvis lesions and the assessment of the biological behavior ofrenal pelvis cancer.