糖皮质激素吸入治疗对哮喘儿童肺功能的影响

Effect of treatment by inhaling glucocorticosteroid on lung function of asthma children

目的探讨不同的糖皮质激素吸入治疗的疗程对哮喘儿童肺功能的影响。方法110例初诊时处于发作期的哮喘儿童年龄（6-14岁）,按糖皮质激素吸入治疗的疗程分成3组,A组（半年期组）50例,B组（1年期组）30例和C组（2年期组）30例,分别在用药前及用药后半年、1年、2年测定肺功能。结果三组患儿用药后肺功能均较用药前明显改善（P〈0.001）,其中大气道功能改善最为迅速,半年即达预计值的80%以上,小气道功能障碍持续存在,随疗程的延长,二年期与半年期相比大小气道功能均有显著性改善（P〈0.05）。结论在儿童哮喘防治中,应坚持小剂量糖皮质激素吸入治疗二年以上。

Objective To explore the effect of different courses of treatment using glucocorticosteroid on lung function of asthma children. Methods 110 cases of asthma children in the asthma attack period participated in the study. The subjects were between 8 and 14 year old and who had their first visit to hospital. Three groups were designed according to course of inhaled glucocorticosteroid in treatment. Group A （half year period） consisted of 50 cases. Group B （one year period） consisted of 30 cases. Group C （two years period） consisted of 30 cases. Lung function of children with asthma were measured before and after inhaled treatment. Results Three groups of lung function of children with asthma after treatment were improved remarkably more than before treatment （ P 〈 0. 001 ）. Large airway function improved very quickly and attached more than 80% of the standard value after the half year＇s treatment. Small airway function obstruction continuously existed. Large and small airway function improved remarkably more in the group C than in the group A in the course of treatment （P 〈 0.05 ）. Conclusion Children with asthma should inhale small doses of glucocorticosteroid over two year period for the prevention and treatment of asthma.