吸入糖皮质激素治疗COPD疗效及安全性研究

The curative effect and security research that inhale cortin to cure COPD

目的观察吸入糖皮质激素对稳定期中重度慢性阻塞性肺疾病（COPD）的疗效和安全性。方法采用随机分组方法对本院2004-2005年门诊患者中筛选出符合入选标准的47例稳定期中重度COPD患者进行随机分组,分别给予布地奈德/福莫特罗干粉吸入剂（治疗组）和福莫特罗干粉吸入剂（对照组）治疗半年,评估肺功能、呼吸困难程度、活动能力及慢性阻塞性肺疾病急性发作（AECOPD）、不良反应等。疗效分析采用t检验或χ^2验。结果47例患者均完成半年随访。治疗结果显示,治疗组第一秒用力呼气容积（FEV1）[（1.28±0.34）L]较对照组[（1.07±0.35）L]增高（t=2.28,P〈0.05）;呼吸困难程度显著好转10例（41.7%）较对照组6例（26.1%）增高（χ^24.756,P〈0.05）;活动能力改善10例（41.7%）较对照组6例（26.1%）增强（χ^24.716,P〈0.05）;AECOPD13例次（44.2%）较对照组16例次（69.6%）减少（χ^24.49,P〈0.05）;两组不良反应比较差异无统计学意义。结论吸入糖皮质激素治疗稳定期中重度COPD安全有效。

Objective To observe curative effect and security research for middle or serious COPD cases of stabilization period when inhaling cortin. Method We screen out 47 middle or serious COPD cases of stabilization period to group at random for our outpatients of 2004 - 2005 period. We give cortin to treat for half year. We evaluate pulmonary function, the degree of dyspnea, activity ability （ AECOPD ） and bad reaction. The curative effect analysis is tested by t-test orχ^2 test. Results All 47 cases are visited within half year period. The analysis conclusion of Curative Group show： The FEV1 [ （ 1.28 ± 0. 34） L] of inhaling cortin Group is higher （ t = 2.28, P 〈 0. 05 ） than Comparative Group [ （ 1.07 ±0. 35 ）L] ;the degree of dyspnea （41.7 % ） of 10 cases of all become better, it is higher （χ^2 = 4. 716, P 〈 0.05 ）than Comparative Group （6 cases,26. 1% ） ; the ability of activity （41.7 % ） of 10 cases of all become better, it is higher（χ^2 = 4. 716,P 〈 0. 05 ） than Compative Group （6 cases,26. 1% ） ; the cases of AECOPD of all （44. 2% ） are lower （χ^2 = 4. 49, P 〈 0. 05 ） than Comparative Group （ 16cases, 69.6% ） ;the comparative difference of bad reaction of the two group is meaningless statistically. Conclusion The treatment of middle or serious COPD cases of stabilization period to inhale cortin is effective and safe.