克拉霉素联合莫沙必利治疗慢性咳嗽并反流性食道炎疗效观察

The Clinical Observation of the Treatment with Clarithromycin combined Mosapride in chronic cough and reflux esophagitis

目的探讨反流性食道炎与慢性咳嗽的关系及克拉霉素联合莫沙必利及法莫替丁治疗慢性咳嗽并反流性食道炎临床疗效。方法选择84例慢性咳嗽并反流性食道炎患者为研究对象,随机分为克拉霉素治疗组(A组)、阿莫西林治疗组(B组)和对照组(C组)。A组采用克拉霉素、莫沙必利及法莫替丁治疗;B组采用阿莫西林、莫沙必利及法莫替丁治疗,C组采用克拉霉素及法莫替丁治疗;疗程为15天,15天后随访所有患者的咳嗽症状及复查胃镜。结果A组及B组的反流性食道炎均比对照组明显好转(P<0.01),同时A组及B组慢性咳嗽症状改善比C组好(P<0.01),而A组慢性咳嗽症状疗效比B组明显提高(P<0.05)。结论反流性食道炎与慢性咳嗽有关,克拉霉素与莫沙必利联合法莫替丁对治疗慢性咳嗽并反流性食道炎中对慢性咳嗽有较好疗效。

Objective To observate the effect of the treatment with Clarithromycin combined with Mosapride and famotidine in chronic cough and reflux esophagitis. Methods 84 patients with chronic cough and reflux esophagitis were divided into group A treated with Clarithromycin combine with Mosapride and famotidine, group B treated with Amoxicillin combined with mosapride and famotidine and group C treated with clarithromycin and famotidine randomly. All patient＇s had been treated for 15 days. And all patient＇s symptom were been visited and detected by gastroscope after 15 days. Results Compared to in group C, reflux esophagitis was improved in group A and group B（P 〈0.01 ）. Meanwhile chronic cough was improved in group A and in group B than in group C（P 〈0.01 ）. And chronic cough was improved in group A than in group B. Conclusion There is correlation between chronic cough and reflux esophagitis. Furthermore, Clarithromycin combine with Mosapride and famotidine can improve the symptom of chronic cough in chronic cough and reflux esophagitis.