熊去氧胆酸防治HBsAg阳性肺结核患者化疗中肝损害的临床观察

A clinical observation of Uusodexycholic acid on prevention and treatment liver function damage of pulmonary TB patients with HBsAg+ during chemical therapy

目的观察熊去氧胆酸片防治HBsAg阳性肺结核患者化疗中肝损害的疗效。方法将152例HBsAg阳性的肺结核患者分为四组,治疗方案均采用2HRZE/4-7HR,分别加熊去氧胆酸片或肝泰乐口服,对比分析四组间肝功能损害的发生率及其他情况。结果熊去氧胆酸片明显降低肝损害的发生。结论熊去氧胆酸片在对阳性肺结核病人化疗中可有效起到保肝作用。

Objective To observe the clinical effect of ursodeoxycbolic acid on prevention and treatment liver function damage of pulmonary tuberculosis （TB） patients with HBsAg positive （ HBsAg ＋ ） during chemical therapy. Methods 152 TB patients with HBsAg ＋ were divided into four groups randomly. All cases were treated with 2HRZE/4 -7 HR and ursodeoxycholic acid or glucurone. The rate of the cases of liver function damage and another toxicity was compared between the two groups. Results The rate of liver function damage in the groups of ursodexycholic acid was lower than that in the groups of glucurone. Conclusion The ursodeoxycholic acid can protect the liver function of pulmonary tuberculiosis patients with HBsAg ＋ during chemical therapy.