摘要
应用薄层色谱扫描法，动态观察了实验性甲低大鼠脑，红细胞膜神经磷脂（ＳＭ）／磷脂酰胆碱（ＰＣ）分子比变化，结果表明持续用甲基硫脲嘧啶（ＭＴＵ）和脑发育临界期后停ＭＴＵ组，ＳＭ／ＰＣ分子比明显升高（Ｐ＜０．０５）。提示脑发育临界期内甲状腺激素缺乏，可导致生物膜的明显老化，膜磷脂分布破坏造成一系列结构和功能的改变，进而使中枢神经系统发育异常和功能障碍。
SM/PC molecule ratio changes in experimental hypothyroidism rats during development was determinated with thin-layer chromatography. Our results showed that SM/PC molecule ratio of brain applying continuously MTU and stopping MTU rats after a critical period was higher than that of control (P<0.05). These data suggested hypothyroidism in a critical period of brain development bring about organism membrane aging and destroy arrangement of membrane phospholipid to create changes of structure and function .It leads to abnormality of development of the central nervous system and disorder of function.
出处
《中国地方病学杂志》
CSCD
1997年第1期12-14,共3页
Chinese Jouranl of Endemiology
关键词
甲状腺机能减退
红细胞膜
磷脂
磷脂酰胆碱
Hypothyroidism
RBC membrane
Brain
Sphingomyelin Phosphatidylcholine
