安乃近溶液鼻粘膜吸收的研究

Analgin nasal absorption

目的：研究安乃近溶液鼻粘膜吸收规律。方法：以大鼠在体鼻循环法为实验模型，考察循环液的体积、流速等对安乃近鼻粘膜吸收的影响。并在体积、流速确定的条件下，考查循环液浓度不同时，安乃近鼻粘膜吸收规律。结果：循环液体积越大，单位时间内粘膜吸收百分率越小；当流速较小时，随着流速的增加，吸收速度常数Ｋ增大，流速超过２．０ｍｌ·ｍｉｎ－１后，Ｋ显著减小；以循环液体积为３ｍｌ，流速２．０ｍｌ·ｍｉｎ－１，考察了５０，１００，１５０，２００ｇ·Ｌ－１安乃近溶液鼻粘膜吸收规律，表明不同浓度的安乃近鼻粘膜吸收速度为一常数。结论：安乃近溶液鼻粘膜吸收机制为被动扩散，吸收符合一级动力学，吸收速度常数Ｋ为０．０２２１９ｍｉｎ－１。

OBJECTIVE:To investigate the regulation of analgin nasal absorption.METHODS:We used rat in situ nasal recirculation methods as experimental model.The effects of perfusion volume,flow rate,perfusion concentration on nasal absorption of analgin were studied.RESULTS:The larger the perfusion volume,the little of the percent absorbed each minute.At first,the absorption rate constant K increased with the increase of flow rate,K decreased significantly while the flow rate was over 2 ml·min -1 ,keeping the perfusion volume 3 ml and flow rate 2 ml·min -1 as a rule,we studied nasal absorption regulation of four concentration:50,100,150,200 g·L -1 ,indicating that the absorption rate of different concentration is a constant.CONCLUSION:The mechanism of analgin nasal absorption is passive diffusion,following first order kinetics,the absorption rate constant is 0.022 19 min -1 .