摘要
以心肌组织ＭＤＡ含量和ＣＰＫ活性及超微结构变化为依据，观察强力宁对家兔心肌缺血再灌注损伤的影响。结果表明，强力宁能明显降低缺血再灌注后心肌组织ＭＤＡ含量和ＣＰＫ活性的升幅（Ｐ＜０．０１），同时，能明显减轻心肌组织超微结构损伤程度。提示强力宁对缺血再灌注损伤心肌具有明显的保护作用。
The content of MDA and the activity of creatine phosphokinase (CPK) together with the ultrastructural changes in myocardial tissue were analysed to observe the effects of glycyrrhisin on myocardial ischemia/reperfusion injury in rabbits. The results showed that glycyrrhisin could remarkably reduced the level of MDA and the activity of CPK in myocardial tissue ( P <0.01), and mitigated significantly the myocrdial ultrastructural injury in comparison with ischemia/reperfusion group. It was considered that glycyrrhisin exerted obvious protective effects on myocardial injury induced by ischemia/reperfusion.
出处
《湖南医科大学学报》
CSCD
1997年第1期69-71,共3页
Bulletin of Hunan Medical University
关键词
心肌缺血
再灌注损伤
强力宁
甘草次酸
超微结构
reperfusion injury
glycyrrhisin *
myocardium
creatine phosphokinase
malon dialdehyde
ultrastructure
rabbits
