心钠素对兔眼压的影响

An experimental study on effect of atrial natrivretic peptide on intraocular pressure of white rabbits

目的探讨心钠素对青光眼的治疗价值。方法对白色家兔结膜下注射不同剂量的心钠素，动态观察心钠素对兔眼压的影响。结果结膜下注射２０、３０、４０μｇ的心钠素，均可见有意义的眼压下降。４０μｇ的心钠素眼压下降幅度最大，维持时间最长，眼压下降高峰时间均在用药后１小时。同时可见随给药浓度增加，眼压下降幅度加大，呈量效关系。结论心钠素可作为一种新的抗青光眼药物应用于临床。

Objective To study the therapeutic effect of atrial natrivretic pepted (ANP) on glaucoma.Methods Various doses of ANP were injected subconjunctivally in albino rabbits,and their effects on intraocular pressures (IOPs) were observed.Results The IOPs were significantly decreased by the subconjunctival injection of 23,30,40ug of ANP,and with a dose of 40 ug,the maximum effect of IOP lowering of 0.88 0.15 kPa maintaining for the longest time 7.5 hours was obtained.Generally,one bour after the injection,the maximum effect could be seen. A dose effect relationship that is the degree of the reduction of IOP increasing with the dose increase of ANP could be observed.Conclusion This study indicates that ANP might play an effective therapeutic role in glaucoma.