参芪片对^(131)I内照射后早发甲低患者作用的研究

Clinical Study of Senqi Tablet on Earily Hypothyroidism After ^(131)I Therapy

目的:探讨参芪片在内照射后早发甲低患者中的临床疗效与治疗方法。方法:早发甲低患者96人,随机分为参芪片治疗组和对照组,每组48人,治疗前后测定血清T3、T4、TSH水平。结果:治疗组和对照组血清T、T水平均较治疗前明显升高,但两组甲状腺血清T3、T4水平比较均未见统计学差异(P>0.05);治疗组和对照组血清促甲状腺素分泌水平下降,治疗组下降幅度较对照组明显,且差异显著(P<0.05)。结论:参芪片联合西药可有效促进放疗后甲状腺组织功能恢复,是临床治疗早发甲低的有效疗法。

Objective To study the influence of Senqi tablet on hypothyroidism after ^131I therapy. Methods Ninety-six patients with early hypothyroidism after ^131I therapy were randomly divided into two groups： the hbo group （n = 48） and the non-hbo group （n =48）. Serum T3, T4 and TSH levels were measured twice （four months apart） with CLIA in both groups. Results Serum T3 and T4 levels were increased significantly in both groups after the four months＇ course of low-dosage thyroid hormone replacement, but there were no significant differences between the final levels in the two groups （P 〉 0.05）. Of TSH levels were lowed significantly in both groups （both P 〈 0.05）, however, the magnitude of lowering was significantly larger in the Senqi group than that in the contrast group （P 〈 0.05）. Conclusion Senqi tablet maybe a potential useful means for treatment of early hypothyroidism after administration of ^131I.