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孤核受体RORα的研究进展 被引量：4

Process of RORα
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摘要 孤核受体RORα作为核受体超家族成员,广泛分布于机体各组织,近年来国外学者对结构、功能做了大量研究,不断发现其通过对目的基因转录调控,在许多重要生理活动发挥重要的调节功能,在对抗心血管疾病、慢性炎症、免疫功能不全、骨代谢障碍、肿瘤等一些病理过程中发挥重要作用。 Retinoic acid receptor-related Orphan Receptor α （RORα） is a member of the nuclear hormone receptor superfamily. RORα is wildly expressed in several organs and tissues in which it acti-vates the transcription of specific genes. RORα plays a major role in cellular differentiation during devel-opment and growth of numerous tissues. RORα has also been shown to be involved in pathophysiologicprocesses, and seems to have a protective role in some diseases.
作者 石莺 苏琦
机构地区 南华大学肿瘤研究所
出处 《国际病理科学与临床杂志》 CAS 2007年第3期257-261,共5页 Journal of International Pathology and Clinical Medicine
关键词 RORα 结构 功能 RORα function structure
分类号 Q343 [生物学—遗传学]
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参考文献50

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  • 5Boukhtouche F,Mariani J,Tedgui A.The "CholesteROR" protective pathway in the vascular system[ J ].Arterioscler Thromb Vasc Biol,2004,24(4):637-643.
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同被引文献43

  • 1范康,傅祥超,范成强,陈琳,文斌.獭兔毛囊分化与被毛生长规律研究[J].中国养兔,2011(12):6-9. 被引量：5
  • 2Solt LA,Griffin PR,Burris TP.Ligand regulation of retinoic acid receptor-related orphan receptors:implications for development of novel therapeutics.Curr Opin Lipidol[J],2010,21(3):204.
  • 3Dong C,Yuan L,Dai J,et al.Melatonin inhibits mitogenic crosstalk between rétinoic acid-related orphan receptor alpha (RORalpha) and ERalpha in MCF-7 human breast cancer cells.Steroids[J],2010,75(12):944-951.
  • 4Odawara H,Iwasaki T,Horiguchi J,et al.Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) alpha in breast cancer cells:identification of a novel ROR response element.J Biol Chem[J],2009,284(26):17711.
  • 5Lee JM,Kim IS,Kim H,et al.RORalpha attenuates Wnt/betacatenin signaling by PKCalpha-dependent phosphorylation in colon cancer.Mol Cell[J],2010,37(2):183-195.
  • 6Boukhtouche F,Mariani J,Tedgui A.The "CholesteROR" Protective Pathway in the Vascular System[J].Arterioscler.Thromb.Vasc.Bio[J],2004,24(4):637-643.
  • 7Jetten AM.Retinoid-related orphan receptors (RORs):critical roles in development,immunity,circadian rhythm,and cellular metabolism[J].Nucl Recept Signal,2009,7:3.
  • 8Soh LA, Griffin PR, Burris TP. Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics [ J ] . Curr Opin Lipidol, 2010, 21(3): 204-211.
  • 9Dong C, Yuan L, Dai J, et al. Melatonin inhibits mitogenic cross-talk between retinoic acid-related orphan receptor alpha (RORalpha) and ERalpha in MCF-7 human breast cancer ceils [ J ] . Steroids, 2010, 75(12): 944-951.
  • 10Odawara H, Iwasaki T, Horiguchi J, et al. Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) alpha in breast cancer cells: identification of a novel ROR response element [ J ] . J Biol Chem, 2009, 284(26): 17711-17719.

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国际病理科学与临床杂志
2007年 第3期

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