期刊文献+

小鼠骨损伤模型在骨修复机制研究中的应用 被引量:8

Use of mouse model to study bone repair
下载PDF
导出
摘要 骨折是常见多发病,建立标准的骨损伤动物模型是进行骨折实验研究的基础,由于小鼠具有和人类相似的遗传背景,并且可进行多种遗传修饰等优势,因此在骨折研究中的应用越来越广泛。 It is very important to study the mechanism of bone repair using animal fracture model. The application of mouse models to study bone repair becomes more extensive, because its genetic background is similar to human and its gene can be modifid easily.
作者 苏楠 陈林
出处 《国际病理科学与临床杂志》 CAS 2007年第3期271-276,共6页 Journal of International Pathology and Clinical Medicine
基金 国家重点基础研究发展规划项目(2005CB522604) 国家自然基金杰出青年基金(30425023) 重庆市科技计划项目(CSTC.2004BA5016)~~
关键词 小鼠 骨折模型 骨损伤模型 mouse fracture model models of bone repair
  • 相关文献

参考文献26

  • 1Le A X,Miclau T,Hu D,et al.Molecular aspects of healing in stabilized and non-stabilized fractures[ J].J Ortho Res,2001,19(1):78-84.
  • 2Hiltunen A,Vuorio E,Aro H T.A standardized experimental fracture in the mouse tibia[J].J Ortho Res,1993,11 (2):305-312.
  • 3Colnot C,Thompson Z,Miclau T,et al.Altered fracture repair in the absence of MMP9[J].Development,2003,130 (17):4123-4133.
  • 4Greiff J.A method for the production of an undisplaced reproducible tibial fracture in the rat[J].Injury,1978,9(4):278-281.
  • 5Einhorn,Bonnarens F,Einhorn T A.Production of a standard closed fracture in laboratory animal bone[J].J Orthop Res,1984,2(1):97-101.
  • 6Maes C,Coenegrachts L,Stockmans I,et al.Placental growth factor mediates mesenchymal cell development,cartilage turnover,and bone remodeling during fracture repair[ J ].J Clin Invest,2006,116(5):1230-1242.
  • 7Gerstenfelda L C,Cho T J,Kon T,et al.Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling[ J ].Cells Tissues Organs,2001,169:285-294.
  • 8Thompson Z,Miclau T,Hu D,et al.A model for intramembranous ossification during fracture healing[J].J Orthop Res,2002,20(5):1091-1098.
  • 9Cheung K M,Kaluarachi K,Andrew G,et al.An externally fixed femoral fracture model for mice[J].J Orthop Res,2003,21 (4):685-690.
  • 10Connolly C K,Li G,Bunn J R,et al.A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals[J].J Orthop Res,2003,21 (5):843-849.

同被引文献114

引证文献8

二级引证文献48

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部