米非司酮与依沙吖啶联合用于中孕引产效果观察

Observation of the Effect of Intermediate Pregnant Amniotomy Using Mifepristone and Ethacridine

目的探讨米非司酮与依沙吖啶联合用于中孕引产效果及其对产程的影响。方法将457例孕16-26周的妇女随机分成两组,观察组227例和对照组230例,观察组经腹壁向羊膜腔内注入依沙吖啶100mg后,空腹分次口服米非司酮最大用药总量为150mg,对照组注药后口服安慰剂,服法同米非司酮。比较两组胎儿胎盘娩出时间、总产程、清宫率、引产成功率及宫颈裂伤发生率、产后出血量。结果观察组自引产开始至胎儿胎盘娩出时间及总产程均较对照组短,宫颈裂伤发生率和清宫率较对照组低,有显著性差异(P<0.01)。产后出血量少于对照组,但差异无显著性(P>0.05)。结论两药联合应用减少了引产孕妇的痛苦和住院时间,是一种较好的中期妊娠的引产方法。

aim-discussing the effect of intermediate pregnant amniotomy using mifepristone and ethacridine and its influence on the course of childbirth. Method-457 women pregnant for 16-26 weeks were divided into 2 groups, observation group （227 women）： injection of 100mg ethacridine by abdominal wall into amniotomic cavity and orally taking 150mg mifepristone twice before eating anything, comparison group （230women）： injection of 100mg ethacridine by abdominal wall into amniotomic cavity and orally taking 150mg placebo twice before eating anything. Comparison of the childbirth time of fetal placenta, total course of childbirth, success rate of amniotomy, cervix lacerated wound, postpartum hemorrhage. Resuh-（observation group） from start of amniotomy to childbirth and total course of childbirth is shorter than that of comparison group. Rate of cervix lacerated wound, postpartum hemorrhage are smaller. Conclusion-it reduces the pregnant women＇s pain and in hospital time using mifepristone and ethacridine, proving to be a fine intermediate pregnant amniotomy .