过敏性紫癜病儿血清LXA_4、LTB_4、IL-5与CRP变化及意义

CHANGES IN SERUM LEVELS OF LIPOXIN A_4, TB_4, IL-5 AND CRP IN CHILDREN WITH HENOCH-SCHONLEIN PURPURA AND THE CORRESPONDING SIGNIFICANCE

目的测定过敏性紫癜病儿在不同发病阶段的血清脂氧素A4(LXA4)、白三烯B4(LTB4)、白介素-5(IL-5)以及C反应蛋白(CRP)变化,以探讨LXA4、LTB4、IL-5和CRP在儿童过敏性紫癜发病机制中的作用。方法采集31例过敏性紫癜病儿急性期和恢复早期血清,以及27例正常儿童(正常组)血清,用酶联免疫吸附试验检测血清中LXA4、LTB4、IL-5和CRP含量。结果过敏性紫癜病儿急性期和恢复早期血清LXA4、LTB4、IL-5和CRP水平均显著高于正常组(F=85.15～345.81,q=7.60～36.98,P<0.01)。过敏性紫癜病儿急性期血清LTB4、IL-5和CRP水平均显著高于恢复早期(q=10.68～20.82,P<0.01);而急性期血清LXA4水平显著低于恢复早期(q=14.72,P<0.01)。结论LTB4和IL-5可能参与过敏性紫癜的病变过程,而LXA4具有抗炎作用。

Objective To investigate the serum levels of lipoxin A4 （LXA4）, leukotriene B4 （ LTB4 ）, interleukin-5 （IL-5） and C-reactive protein （CRP） in children with Henoch-Schonlein purpura （HSP） in different phases and to explore the role of LXA4, LTB4, IL5 and CRP in the pathogenesis of the disease. Methods The serum LXA4, LTB4, IL-5 and CRP in 27 normal children and 31 HSP in cute phase and early recovery phase were detected by ELISA, respectively. Results The serum LXA4, LTB4, IL-5 and CRP in the patients in acute and early recovery phase were significantly higher than that in normal group （F= 85. 15-345.81,q=7.60-36.98,P〈0.01）, LTB4, IL-5 and CRP in acute phase were significantly higher than that in early recovery phase （q=10.68-20.82,P〈0.01）. However, the serum level of LXA4 in the patients in acute phase was significantly lower than that in the early recovery phase （q=14.72,P〈0.01）. Conclusion LTB4 and IL-5 may be involved in the pathological changes of HSP and LXA4 possesses an anti-inflammatory action.