^(188)Re-放射性支架治疗食管恶性狭窄的效果

EFFECT OF ^(188)Re RADIO-ACTIVE ISOTOPE STENT IN THE TREATMENT OF MALIGNANT STRICTURE OF ESOPHAGUS

目的观察采用188Re放射性核素支架并结合专科护理治疗食管恶性狭窄的效果。方法将188Re放射性支架置入食管恶性狭窄病人食管腔内,另以常规覆膜支架作为对照,观察临床疗效和放射反应。结果188Re放射性支架治疗食管恶性狭窄的缓解率为93.33%,中位生存期14个月;对照组分别为60.00%和9个月,两组差异有显著性(χ2=4.66、5.72,P<0.05)。188Re放射性支架治疗Ⅱ级放射反应发生率为40%(6/15)。结论188Re放射性支架治疗食管恶性狭窄效果明显优于覆膜支架,放射性核素支架的护理在提高临床疗效和改善生活质量方面发挥着重要作用。

Objective To study the effect of ^188Re radio-active isotope stent for malignant esophageal stricture.Methods A ^188Re radioactive isotope stent was inserted into the stricture in esophagus and a membrana tectoria stent was used as control. The efficacy and radioreaction were observed. Results The remission rate was 93.33% and mid survival time was 14 months, vs 60.00% and 9 months in the control. The difference between the two groups was significant （χ^2 = 4. 66,5. 72;P〈 0.05）. The grade Ⅱ radioreaction rate in the experiment group was 40% （6/15）. Conclusion A 188 Re radioactive isotope stem is superior to membrana tectoria stent in the treatment of malignant stricture of esophagus.