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雌激素受体α基因多态性与原发性骨质疏松症的关系 被引量:5

RELATIONSHIP BETWEEN THE POLYMORPHISM OF α-GENE OF ESTROGEN RECEPTOR AND PRIMARY OSTEOPOROSIS
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摘要 目的探讨山东半岛地区汉族绝经女性雌激素受体α(ESRα)基因多态性与原发性骨质疏松症的关系。方法选取106例长期居住于山东半岛地区的绝经且患有骨质疏松症的汉族妇女(骨质疏松组)及82例绝经且未患骨质疏松症的汉族妇女(对照组),观察其ESRα基因多态性与骨质疏松症的关系。结果骨质疏松组和对照组基因型及等位基因频率分布比较,差异无显著性(χ2=0.025~5.979,P>0.05)。结论山东半岛地区绝经女性ESRα基因多态性与原发性骨质疏松症不存在相关性。 Objective To investigate the relationship between the polymorphism of α-gene of estrogen receptor (ESR-α gene) and osteoporosis in postmenopausal women of Han people in Shandong peninsula. Methods Postmenopausal women with osteoporosis (osteoporosis group, n= 106) and postmenopausal women without osteoporosis (control group, n=82) were included in this study. The relationship between the polymorphism of ESR-α gene and osteoporosis was evaluated. Results Genotype and the distribution of allele frequency were not found significantly different between osteoporosis group and control group (X^2= 0.025-5. 979,P〉0. 05). Conclusion There is no association between the polymorphism of ESR-α gene and osteoporosis in postmenopausal women of Han people in Shandong peninsula.
出处 《青岛大学医学院学报》 CAS 2007年第4期359-360,共2页 Acta Academiae Medicinae Qingdao Universitatis
关键词 骨质疏松 绝经后 受体 雌激素 基因型 基因频率 osteoporosis, postmenopausal receptors, estrogen genotype gene frequency
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