血浆置换治疗格林-巴利综合征疗效分析

Plasmapheresis for Treating Guillain-Barre Syndrome

目的观察血浆置换对格林-巴利综合征的治疗效果。方法对9例格林-巴利综合征患者进行血浆置换治疗,治疗前后观察神经功能改善状况,检测置换前后血液免疫系列、补体系列及置换后弃浆液的免疫系列、补体系列。结果5例痊愈,3例好转,1例无效。患者血液中的补体及免疫球蛋白治疗后均明显下降,弃浆液补体免疫球蛋白明显高于血液。结论血浆置换是治疗重症格林-巴利综合征较为有效的方法,可能与降低血液中免疫球蛋白及补体有关。

Objective To investigate the effect of plasmapheresis on patients with Guillain-Barre syndrome. Methods Nine patients of Guillain-Barre syndrome were treated with plasmapheresis. The change of neurological functions was observed before and after the treatment. The immunoglobulin and complement in blood were measured hefore and after the therapy and in the discarded plasma. Results Five cases of patients fully recovered and three cases were improved, one （lied, Both immunoglobulin and complement in blood greatly decreased and both immunoglobulin and complement in discarded plasma were higher than those in blood. Conclusions Plasmapheresis is effective for patients with Guillain-Barre syndrome prohably by decreasing immunoglobulin and complement in blood.