长托宁在小儿气管异物取出术中的应用

Application of Penehyclidine Hydrochloride in Removal Operation of Foreign Bodies in Trachea of Children

目的比较长托宁(盐酸戊乙奎醚)、阿托品在小儿气管异物取出术中的应用效果。方法选择36例ASAⅠ级,需气管异物取出的患儿,随机分成A组(长托宁组)和B组(阿托品组),施行静脉复合麻醉。所有病例均采用DASH4000多功能监测仪连续无创监测MAP、HR、SPO2变化,并在给药前及给药后3,6,10,15,30,60min记录以上各项参数,同时记录呼吸道分泌物量。结果B组HR和呼吸道分泌物的量较A组增高,差异有统计学意义(P<0.05),而MAP和SPO2在两组差异无统计学意义(P>0.05)。结论在小儿气管异物取出术,术前应用新型抗胆碱药长托宁比传统药物阿托品更为安全。

Objective To compare the effects of Penehyclidine hydrochloride（PHC） and atropine in the removal operation of foreign body in trachea of children. Methods Thirty six children with foreign body in trachea were randomly divided into two groups. Venous combined anesthesia was used in the both group （group A with PHC,group B with atropine）. MAP, HR,SPO2 was checked continuously by multi-function monitor at 0,3,6,10,15,30,60 min after administration. The amount of secretion in respiratory tract was also recorded at the same time. Results HR and the amount of secretion in group B were higher than that in group A and had statistical differences （ P 〈 0.05 ）. There was no significant difference in MAP and SPO2 between the two groups. Conclusions Pretreated with PHC could be better than with atropine in the removal operation of foreign body in trachea of children.