电针对干燥综合征患者性激素水平影响的研究

Effect of Electroacupuncture on Sex Hormone Levels in Patients with Sjgren's Syndrome

目的:观察电针对干燥综合征患者体内性激素水平的调节作用,分析性激素水平的变化与患者临床症状改善的关系,为临床治疗干燥综合征提供依据。方法:选择57例中老年女性患干燥综合征患者,随机分为治疗组(30例)和对照组(27例)。治疗组采用电针治疗8周,选穴为肾俞、太溪、合谷、廉泉、百会、三阴交、血海。对照组用西药治疗8周,药物为羟氯奎(每日6 mg/kg),转移因子口服液(3次/日,每次1支),维生素(B1、B2、C、鱼肝油,3次/日,每次1片),匹鲁卡品(20 mg/日)。治疗前后两组患者分别采集静脉血,检测体内性激素水平的变化情况,同时观察性激素水平变化与临床症状改善的关系。结果:治疗后两组的性激素指标比较,其中雌二醇(E2)、睾酮(T)、促黄体生成素(LH)存在显著性差异(P<0.01);治疗组治疗前后自身比较也有显著性差异。临床症状也随性激素水平的变化而改善。结论:电针能够改善干燥综合征患者体内紊乱的性激素水平,其疗效优于西药。

Objective：To observe the effect of electroacupuncture （EA） on serum testosterone （T）, estradiol （E2）, luteotropic hormone （LH）, follicle-stimulating hormone （FSH）, progesterone （P）, and prolactin （PRL） in patients with Sjoegren＇s Syndrome （SS） in order to analyze the correlation between the adjustment effect of EA and changes of hormone levels. Methods： Fifty-seven middle-aged and old women with SS were divided into medication group （n = 27） and acupuncture group （n = 30）. Patients in acupuncture group were treated with EA （80 Hz, 2. 5 mA） of Shenshu （BL 23）, Taixi （KI 3）, Hegu （LI 4）, etc. for 30 min, once every other day, and those of medication group were treated with oral administration of hydroxyl-chloroquine （6 mg/kg per day）, oral transfer agent liquid, Vit B1, Vit BE, Vit C, fish-liver oil, one tablet/time, t. i. d., and pilocarpine （20 mg/d）, continuously for 2 months. Venous blood samples were collected before and after the treatment to examine contents of the abovementioned sex hormones by using electro-chemiluminescent immunoassay （CLIA）. Results： 1 ） Before the treatment, no significant differences were found between two groups in the levels of serum T, E2, LH, FSH, P and PRL （ P〉0.05）. After the treatment, self-comparison of each group showed that serum E2 and T contents in acupuncture group increased significantly （P〈0.01） and serum LH content decreased significantly （P〈0.01）; while in medication group, only serum LH decreased markedly （P〈0.05） in comparison with its basic value of pretreatment. No significant changes were found in serum P, FSH and PRL levels in both groups after the treatment （P〉0.05）. The results suggested that the therapeutic effect of acupuncture group was better than that of medication group in regulating multiple sex hormones. Conclusion： EA can effectively adjust E2, T and LH levels in Sjoegren＇s Syndrome patients and improve most patients＇ clinical symptoms, and the therapeutic effect of EA is better than that of medication.