新型3,5-二芳基吡唑衍生物的合成与抑菌活性

Synthesis and Fungicidal Activity of Novel 3,5-Diarylpyrazole Derivatives

以2-氯苯甲醛与2,4-二氯苯乙酮缩合形成α,β不饱和酮,然后和水合肼关环形成3-(2,4-二氯苯基)-5-(2-氯苯基)吡唑结构骨架,合成了8个未见文献报道的3-(2,4-二氯苯基)-5-(2-氯苯基)-4,5二氢-N-酰基吡唑类衍生物。经过元素分析、红外光谱、核磁共振氢谱测试技术对其结构进行了表征。对新合成的化合物进行了初步生物活性测试结果表明,在化合物的质量浓度为50 mg/L时,化合物3f对水稻纹枯菌和稻瘟病菌的抑菌率分别为55.2%和57.1%。化合物3g对水稻纹枯菌、稻瘟病菌和油菜菌核菌的抑菌率分别为52.3%、60.0%和50.4%。

（E） -3- （ 2-chlorophenyl ） -1 - （ 2,4-dichlorophenyl ） prop-2-en-1 -one was prepared from 2-chlorobenzaldehyde followed by cyclization with hydrazine monohydrate. Eight new derivatives of 3-（2,4-dichlorophenyl）-5- （2-chlorophenyl）-4,5-dihydro-N-acylpyrazole were synthesized and characterized by elemental analysis, IR and I H NMR. The experimental results show that the inhibition rates of compound 3f toward H. Oryzae and P. oryzae at 50 mg/L were 55.2% and 57. 1%, respectively, and the inhibition rates of compound 3g toward H. Oryzae, P. oryza, and S. Sclerotiorum. at 50 mg/L were 52. 3%, 60. 0% and 50. 4%, respectively.