摘要
目的:对苯佐卡因的合成工艺进行探索。方法:以对硝基苯甲酸为起始原料,经酯化,还原两步合成苯佐卡因。结果:目标化合物经红外、熔点确证,总收率为55%。结论:该工艺操作简便,适用于学生实验的教学。
Objective. To improve the preparation of benzocaine. Methods： Benzocaine was synthesized from p-nitrobenzoic acid via two steps through esterifying and reduction. Results. The structure of final compoud was confirmed by IR,melting point,and the overall yield was 55%. Conclusion. The method is simple and suitable for the teaching of medicinal chemistry experiment.
出处
《海南医学院学报》
CAS
2007年第2期164-165,共2页
Journal of Hainan Medical University
关键词
药物
麻醉
局部
合成
Medicinal chemistry
Local anesthetics, benzocaine
Synthesis
