经肝动脉热化疗及热碘油栓塞治疗原发性肝癌

Clinical application of transcatheter arterial thermo-chemotherapy and thermo-lipiodol embolization in treatment of hepatocellular carcinoma

目的评价经肝动脉热化疗及热碘油栓塞治疗原发性肝癌的疗效。方法将116例原发性肝癌分为3组。A组(常规组)38例,采用常温动脉灌注化疗及常温碘油栓塞。B组40例,采用热化疗及常温碘油栓塞。C组38例,采用热化疗及热碘油栓塞。B组加C组为热疗组。结果热疗组肿瘤缩小率优于常规组,3组术后肝功能变化情况无显著性差异。6、12、18、24个月生存率常规组分别为97%、58%、39%和18%,热疗组分别为99%、79%、57%、36%。B组和C组间在肿瘤缩小率及生存率方面均无显著性差异。结论肝动脉热化疗栓塞治疗原发性肝癌有明显的疗效,而对肝功能无明显的损害。

Objective To evaluate the clinical efficacy of thermo-chemotherapy and thermo-lipiodol embolization intreatment of primary hepatocellular careinoma（PHC）. Methods One hundred and sixteen cases of PHC were divided into three groups. Group A （38 cases）was treated with normal temperature chemotherapy and normal temperature lipiodol, Group B（40 cases）with thermo-chemotherapy and normal temperature lipiodol and group C （38 cases）with thermo-chemotherapy and thermo-liplodol. Group B and group C were called the thermotherapy group. Results In the thermotherapy groups, the rates of tumor size reduction were significantly greater than those in the normal group. There were no significant different in the hepatic function tests among the three groups. The 6-, 12-, 18-, and 24- month survival rates of the normal group and thermotherapy groups were 97%,58%, 39% and 18%, versus 99%, 79%, 57% and 36%, respectively. No significant differences were found in the rates of reduction of tumor size and survival rates between group ＇B and group C. Conclusion Thermo-chemotherapy and thermo-embolization possess significant effect on PHC but without conspicuous damage to liver function.（J Intervent Radiol, 2007, 16： 384-386）