变形杆菌感染特征及药敏分析

Feature of Proteus infection and drug sensitivity analysis

目的了解变形杆菌感染的分布特点及用药方向,为预防和治疗因变形杆菌感染所致的疾病提供用药依据。方法对本院2005年6月至2006年12月门诊及住院患者进行细菌培养及药敏试验,将变形杆菌阳性的病例进行回顾性分析,根据分布特点进一步调查其致病倾向。结果74例变形杆菌感染者,其中46例是从腹泻患者的粪便中培养分离出来的(62.2%),而这46例患者腹泻大多发生在夏季(7～9月份38例,占82.6%),其中有19例发生溃疡性肠炎。在变形杆菌的药敏试验中,对舒普深、妥布霉素的敏感率达100%。结论变形杆菌是引起夏季腹泻的主要病原菌之一,而且也是溃疡性肠炎的致病因素之一。

Objective To understand the distribution charateristics of Proteus infection and the direction of making drugs for providing basis to treat the diseases caused by Proteus infection. Methods To select the patients from June,2005 to December,2006 in our hospital, then to perform bacteria culture and drug sensitivity tests. The cases with positive culture of Proteus infection were analyzed retrospectively, then the patogenic trends were investigated according to the distributed feature of Proteus infection. Results Forty-six （62.2%） among 74 isolates came from stool in the patients with diarrhea occured mostly in summer. 38 cases （82. 6%） had the onset from June to Septemble. Among them, 19 developed ulcerative colitis. In the drug sensitivity tests of Proteus, the sensitivity rate for sulperazone and tobramycin reached 100%. Conclusion Proteus is one of the main pathogenic bacteria causing summer diarrhea, and is also one of the pathogenic factors leading to ulcerative colitis.