大豆异黄酮对大鼠脂质的影响及减肥作用研究

Effect of Soybean Isoflavonet on Lipid Metabolism and Weight Control of the Obese Rats

目的建立大鼠肥胖和高脂模型,观察大豆异黄酮对肥胖、高血脂大鼠的减肥降脂作用,并研究其作用机理。方法选用SD雄性大鼠、喂饲高脂饲料,建立肥胖和高血脂模型,对大豆异黄酮进行减肥降脂试验。结果大豆异黄酮中、高剂量组均能明显降低高血脂大鼠血清胆固醇(TC)、甘油三脂(TG)和低密度脂蛋白(LDL—C)含量;高剂量组能明显提高大鼠血清高密度脂蛋白(HDL—C)含量,同时也明显降低肥胖大鼠的体重和体内脂肪重。结论大豆异黄酮具有减肥降脂作用,其机理可能与调节机体脂质代谢有关。

Objective To investigate the effect of soybean isoflavonet on lipid metabolism and weight control of experimental hyperlipidemla rats and obese rats, and to study its mechanism. Methods Male obese rats and atherosclerotlc rats which induced by high fat diet were randomly divided into four groups respectively. The control group was garaged with normal saline and the soy isoflavonet groups were gavnged with water solutions of soy isoflavonet at different doses （60, 120 and 360mg/kg, respectively）. And body weight, fat weight, serum total triglyceride （TG）, total cholesterol （TC）, low density lipeprotein cholesterol （LDL-C） and high density lipeprotein cholesterol （HDL-C） were measured after four weeks. Results The concentrations of TC, TG and LDL-C in middle and high dose group were all significantly decreased compared with control group. And the serum level of HDL-C in high dose group significantly increased with body weight, and the fat weight of obsess rats decreased compared with control group. Conclusions Soy isoflavonet may be beneficial on weight control and serum llpids reducing by regulating lipid metabolism.