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肝脂酶基因-514C/T变异对血脂的影响 被引量：1

Influence of hepatic lipase gene C-514T variants on blood lipids
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摘要 目的:探讨肝脂酶(HL)基因启动子-514C/T变异是否影响血脂水平。方法:选入符合录用标准者322例作血脂测定,从全血中用DNA试剂盒提取DNA,采用聚合酶链式反应-限制性片断多态性方法检测HL基因多态性。结果:在调整年龄和体重指数(BMI)后,HL-514C/T基因型对血清高密度脂蛋白胆固醇(HDL-C)的水平影响有统计学意义(P<0.01),其高低是T/T+T/C>C/C,这种效应与男性关系明显(P<0.01),但与女性关系不明显。结论:肝脂酶基因-514C/T变异可影响血脂水平,且存在男女性别差异,各HL基因型的分布无性别差异。 Objective：To investigate whether the promoter 514C/T of hepatic lipase （HL） variants affect blood lipids level. Methods： Three hundred and twelve subjects were studied. The serum lipid and apolipoprotein were measured by enzymatic methods and the genomic DNA was isolated from peripheral blood by DNA isolation kit. Polymerase chain reaction and restricted fragments polymorphism were used to determine HL genotype. Results：After adjusting age and BMI, the influence of HL genotype on profiles of HDL-C levels had staticstical significance（ P 〈0.05 ） with values in the order of T/T ＋ T/C 〉 C/C. This effect appears more evident in male than in female（P 〈 0.01 and P 〈 0.05） . Conclusions： HL-514C/T gene variants affect blood lipids and there exists gender difference, however the difference is not significant among the HL genotypes.
作者 姚友权 徐力辛 熊术道
机构地区 温州医学院第一附属医院心内科 温州医学院第一附属医院医科所
出处 《蚌埠医学院学报》 CAS 2007年第4期431-434,共4页 Journal of Bengbu Medical College
关键词 血脂蛋白过多 肝脂酶 基因 调节 变异 hyperlipoproteinemia hepatic lipase genes, regulator variation
分类号 R589.2 [医药卫生—内分泌]
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参考文献16

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同被引文献23

  • 1李宏义,鄢盛恺,严晓伟.汉族人肝脂酶基因启动子-514C/T多态性与2型糖尿病合并冠心病的关系[J].中华检验医学杂志,2005,28(4):373-377. 被引量：3
  • 2Zambon A,Deeb SS,Pauletto P,et al. Hepatic lipase:a marker for cardiovascular disease risk and response to therapy[J]. Curr Opin Lipidol,2003,14 (2) : 179-189.
  • 3Pihlajamaki J, Karijainen L, Karhapaa P, et al. G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia[ J]. Arterioscler Thromb Vasc Biol,2000,20(7) :1789-1795.
  • 4Jansen H,Waterworth DM,Nicaud V,et al. Interaction of the common apolipoprotein C-Ⅲ ( APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study Ⅱ ( EARS- Ⅱ) [J]. Ann Hum Genet,2001,65(3) :237-243.
  • 5Yabu Y,Noma K,Nakatani K,et al. C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects[J]. Int J Mol Med,2005,16(3) :421-425.
  • 6Gomez P, Perez-Jimenez F, Marin C ,et al. The -514 C/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population [ J ]. J Mol Endocrinol, 2005,34(2) :331-338.
  • 7Zambon A, Deeb SS, Hokanson JE, et al. Common variants in the promoter of the heptic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 choleaterol [ J ]. Arterioscler Thomb Vasc Biol, 1998, 18 ( 11 ) : 1723 -1729.
  • 8Todorova B, Kubaszek A, Pihlajamaki J, et al. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study [ J ]. J Clin Endoerinol Metab,2004, 89(5) :2019-2023.
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  • 10Lewis GF,Murdoch S,Uffelman K,et al. Hepatic lipase mRNA, protein,and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone [ J]. Diabetes ,2004,53 ( 11 ) :2893-900.

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蚌埠医学院学报
2007年 第4期

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