65例危重病性多发性神经病的临床分析

CLINICAL ANALYSIS OF 65 CASES CRITICAL ILLNESS POLYNEUROPATHY PATIENTS

目的为危重病性多发性神经病（CIP）防治提供依据。方法回顾性分析ICU3年内出现的65例CIP．总结其临床特点、发病相关因素及转归；并用SPSS10．0软件统计分析。结果CIP临床特点为四肢肌无力98．5％、呼吸肌无力86．1％，均有肌肉萎缩（100．0％）；发病与脓毒症、MODS、应用镇静药、肌松药及氨基糖甙类、万古霉素、住ICU时间长、机械通气时间长、应用静脉营养等相关，均有统计学意义。结论CIP临床以四肢肌（或呼吸肌）无力伴肌肉萎缩为特点，多在第3—4周发病，与多种因素有关，预后尚好。

Objective To analyze the risk factor, clinical characteristic, treatment and outcome of the critical illness polyneuropathy （CIP） in intensive care unit（ICU）. Method 65 cases of CIP were retrospectively analyzed in the ICU during the recent 3 years. Analyze the risk factor, clinical characteristic, treatment and outcome by SPSS 10.0 software. Result The clinical characteristics of CIP are weakness of four limbs （98.5%） , respiratory muscles weakness （86.1%）, muscles atrophy （100.0%）. Its occurrence was statisticly significantly related with sepsis, multiple organ dysfunction syndrome（MODS） , apllying with long time ventilation, apllying with TNA, etc. Conclusion Clinical characteristics of CIP were weakness of four limps （ or respiratory muscles） which were related with several factors. The prognosis of the patients was well.