HIF-1通路在低氧对成肌细胞增殖分化影响中的作用

Role of HIF Signaling Pathway Involved in Effects of Hypoxia on Proliferation and Differentiation of Myoblasts

氧是在环境中存在的并在发育过程中起作用的信号分子,调控着细胞的能量代谢、生长和分化。骨骼肌中存在着具有自我更新和分化为肌纤维能力的成肌细胞,出生后成肌细胞在骨骼肌的损伤修复和维持中起重要作用。尽管氧在几乎所有高级生命活动中具有重要作用,但有关氧水平对成肌细胞增殖和分化的影响的研究甚少。体内生理性和病理性微环境的氧浓度是处于低水平的,本文就低氧对成肌细胞增殖和分化的影响,以及HIF-1信号通路在其中的作用进行了综述。

Oxygen is an environmental and developmental signal regulator, involved in energy homeostasis, development and process of differentiation. Myoblasts persist in skeletal muscle as satellite cells, which possess capability of self-renewing and differentiation into mature myofiber. Myoblasts play an important role in postnatal muscle regeneration after injury as well as maintaining myofibers＇ function. Though oxygen is vital to nearly all forms of life, little is known on the effects of oxygen level on proliferation and differentiation of myoblasts. The level of oxygen in physiological and pathological microenvironment in vivo is low. This review summarizes recent advances in the study of the effects of hypoxia on proliferation and differentiation of myoblasts and HIF signaling pathway involved in these processes.