期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ghrelin与生殖 被引量：6

下载PDF
导出
摘要 ghrelin是1999年发现的一个含有28个氨基酸残基的多肽,为生长激素促分泌素受体(GHS-R)的内源性配体。具有调节能量平衡等多种生物学功能。近年来许多研究表明ghrelin对生殖激素、性腺、胎儿的发育、妊娠和泌乳均有一定的影响,并且,ghrelin及其受体广泛存在于生殖轴中。提示ghrelin对生殖系统具有重要的调节作用。
作者 方富贵 章孝荣
机构地区 安徽农业大学动物科技学院
出处 《生理科学进展》 CAS CSCD 北大核心 2007年第3期248-251,共4页 Progress in Physiological Sciences
基金 安徽省教育厅青年基金资助课题(2005JQ1059)
关键词 GHRELIN 生殖 胚胎 性腺 妊娠
分类号 Q492 [生物学—生理学]
  • 相关文献

参考文献9

  • 1王楠,刘志敏,刘党生.生长激素促释放剂受体配体的研究进展[J].生物技术通讯,2005,16(3):320-322. 被引量：5
  • 2Martini AC,Ferná-Fernáez R,Tovar S,et al.Comparative analysis of the effects of ghrelin and un-acylated ghrelin upon luteinizing hormone secretion in male rats.Endocrinology,2006,147:2374～2382.
  • 3Kellokoski E,Poykko SM,Karjalainen AH,et al.Estrogen replacement therapy increase plasma ghrelin levels.J Clin Endocrinol Metab,2005,90:2954～2963.
  • 4Lebenthal Y,Gat-Yablonski G,Shtaif B,et al.Effect of sex hormone administration on circulating ghrelin levels in peripubertal children.J Clin Endocrinol Metab,2006,91:328～331.
  • 5Nakahara K,Nakagawa M,Baba Y,et al.Maternal ghrelin plays an important role in rat fetal development during pregnancy.Endocrinology,2006,147:1333～1342.
  • 6Tena-Sempere M.Ghrelin:novel regulator of gonadal function.J Endocrinol Invest,2005,28(5 Suppl):26～29.
  • 7Miller DW,Harrison JI,Brown YA,et al.Immunohistochemical evidence for an endocrine/paracrine role for ghrelin in the reproductive tissues of sheep.Reprod Biol Endocrinol,2005,3:60.
  • 8Fernandez-Fernandez R,Navarro VM,Barreiro ML,et al.Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat.Endocrinology,2005,146:3018～3025.
  • 9Kierson JA,Dimatteo DM,Locke RG,et al.Ghrelin and cholecystokinin in term and preterm human breast milk.Acta Paediatr,2006,95:991～995.

二级参考文献42

  • 1Pombo M.Hormonal control of growth hormone secretion[J].Horm Res, 2001,55(suppll):11.
  • 2Bowers CY.Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro[J]. Endocrinology,1980,106:663.
  • 3Bowers CY.On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone[J].Endocrinology,1984,114:1537.
  • 4Smith RG.A nonpeptidyl growth hormone secretagogue[J].Science, 1993,260:1640.
  • 5Patchett AA.Design and biological activities of L-163,191(MK-0677): a potent,orally active growth hormone secretagogue[J].Proc Natl Acad Sci USA,1995,92:7001.
  • 6Akman MS.Mechanisms of action of a second generationgrowth hormone-releasing peptide in rat anterior pituitary cells[J]. Endocrinology,1993,132:1286.
  • 7Cheng K.The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3",5"-monophosphate accumulation in rat primary pituitary cell culture[J].Endocrinology,1989,124:2791.
  • 8Sano T,Asa SL,Kovacs K.Growth hormone-releasing hormone-producing tumours;clinical,biochemical,and morphological manifestations[J]. Endocr Rev,1998,3:357.
  • 9Lanis CA,Masters SB,Spada A,et al.GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours[J].Nature,1999,340:692.
  • 10Shimon I,Melmed S.Pituitary tumour pathogenesis[J].J Clin Endocrinol Metab,1997,82:1675.

共引文献4

同被引文献60

引证文献6

二级引证文献10

生理科学进展
2007年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部